AB.withDescalation(TrialSize)
AB.withDescalation()所属R语言包：TrialSize
A + B Escalation Design with Dose De-escalation
A + B升级的设计与剂量的降阶梯
译者：生物统计家园网 机器人LoveR
描述----------Description----------
The general A+B designs with dose de-escalation. There are A patients at dose level i.
一般的A + B设计与剂量降级。在剂量水平，我有一个病人。
(1) If less than C/A patients have dose limiting toxicity (DLTs), then the dose is escalated to the next dose level i+1.
（1）如果低于C / A患者有剂量限制性毒性（DLTS），然后剂量升级到下一个剂量水平，我+1。
(2)If more than D/A (D>=C) patients have DLTs, then it will come back to dose i-1.If more than A patients have already been treated at dose level i-1, it will stop here and dose i-1 is the MTD. If there are only A patients treated at dose i-1, then Bmore patients are treated at this dose level i-1. This is dose de-escalation. The de-escalation may continue to the next dose level i-2 and so on if necessary.
（2）如果超过D / A（D = C）患者双腔，然后它会回来我如果多一个患者的剂量已经治疗剂量水平的i-1，它会停在这里和剂量i-1是在MTD。如果只有一个I-1剂量治疗的患者，然后Bmore的患者的治疗都在此剂量水平的i-1。这是剂量降级。升级可能继续到下一个剂量水平I-2，如果必要。
(3)If no less than C/A but no more than D/A patients have DLTs, B more patients are treated at this dose level i.
（3）如果不低于C / A，但不超过D / A患者有双腔，B患者治疗剂量水平，我在此。
(4)If no more than E (where E>=D) of the total A+B patients have DLT, then the dose is escalated.
（4）如果没有超过E（E> = D）的总的A + B患者有DLT，然后剂量升级。
(5)If more than E of the total of A+B patients have DLT, and the similar procedure in (2) will be applied.
（5）如果有更多的比E的总量，A + B患者有DLT，和类似的操作，在（2）将施加。
用法----------Usage----------
AB.withDescalation(A, B, C, D, E, DLT)
参数----------Arguments----------
参数：A
number of patients for the start A
患者人数开始
参数：B
number of patients for the continuous B
的连续“B”的患者数量
参数：C
number of patients for the first cut off C
患者人数为先切断Ç
参数：D
number of patients for the second cut off D, D>=C
数量的患者为第二切关D，D> = C
参数：E
number of patients for the third cut off D, E>=D
患者人数的三分之一切关D，E = D
参数：DLT
dose limiting toxicity rate for each dose level.
每个剂量水平的剂量限制性毒性率。
注意----------Note----------
For this design, the MTD is the dose level at which no more than E/(A+B) patients experience DLTs, and more than D/A or (no less than C/A and no more than D/A) if more than E/(A+B) patients treated with the next higher dose have DLTs.
对于这个设计，MTD是剂量不超过E /（A + B）患者的经验双腔，多D / A或（不低于C / A和D / A不超过）如果有更多的比E /（A + B）与下一个更高的剂量治疗的患者有DLTS。
参考文献----------References----------
实例----------Examples----------
Example.11.6.2<-AB.withDescalation(A=3,B=3,C=1,D=1,E=1,DLT=c(0.01,0.014,0.025,0.056,0.177,0.594,0.963))
Example.11.6.2
# Example.11.6.2[7]=0.2 [example.11.6.2 [7] = 0.2]
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注：
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发表于 2012-10-1 11:55:51
