norm2c(nudge)
norm2c()所属R语言包：nudge
Function for normalizing the mean of average-across-replicates log ratio differences
功能标准化平均平均的跨越，复制记录比例差异
译者：生物统计家园网 机器人LoveR
描述----------Description----------
This normalization is used when the two samples (control and treatment, say) are not being directly compared on the slides but instead are being compared to a common reference sample. The quantity of interest for each gene is thus the average difference between control and treatment log ratios. The normalization is done for each gene by subtracting from its average-across-replicates log ratio difference the loess estimated mean for average-across-replicates log ratio difference based on the loess regression of average-across-replicates log ratio differences on average-across-replicates log total intensities.
这个标准化是用来当两个样本（控制和治疗，说）没有直接上的幻灯片相比，但取而代之的是一个共同的参考样本进行比较。因此，利息每一个基因的数量是控制和治疗的log比率之间的平均差异。每个基因标准化减去其平均跨重复数比差的黄土估计意味着平均全面复制log比率差异的基础上的局部加权回归平均全面复制log的比例差异，平均跨 - 重复登录的总强度。
用法----------Usage----------
norm2c(control.logratio, txt.logratio, control.logintensity, txt.logintensity,
span = 0.6)
参数----------Arguments----------
参数：control.logratio
A multiple-column matrix of replicates of log (base 2) ratios of gene expressions for the control versus reference slides.
一个多列的矩阵复制log（基数为2）基因表达与参考幻灯片的控制比例。
参数：txt.logratio
A multiple-column matrix of replicates of log (base 2) ratios of gene expressions for the treatment versus reference slides.
一个多列的矩阵复制log（基数为2）基因表达的治疗与参考幻灯片比例。
参数：control.logintensity
A multiple-column matrix of replicates of log (base 2) total intensities (defined as the product) of gene expressions for the control versus reference slides.
一个多列的矩阵复制log（基数为2）总强度与参考幻灯片控制基因表达（定义为产品）。
参数：txt.logintensity
A multiple-column matrix of replicates of log (base 2) total intensities (defined as the product) of gene expressions for the treatment versus reference slides.
一个多列的矩阵复制log（基数为2）（定义为产品）的基因表达，为治疗与参考幻灯片的总强度。
参数：span
Proportion of data used to fit the loess regression of the average-across-replicates log ratio differences on the average-across-replicates log total intensities.
适合局部加权回归用于数据的比例平均全面复制log的比例差异的平均跨重复记录的总强度。
值----------Value----------
A vector of mean normalized average-across-replicates log ratio differences.
一个矢量的平均归平均全面复制log的比例差异。
作者（S）----------Author(s)----------
N. Dean and A. E. Raftery
参考文献----------References----------
参见----------See Also----------
norm2d,norm1a,norm1b,norm1c,norm1d
norm2d，norm1a，norm1b，norm1c，norm1d
举例----------Examples----------
apo<-read.csv("http://www.stat.berkeley.edu/users/terry/zarray/Data/ApoA1/rg_a1ko_morph.txt",
header=TRUE)
rownames(apo)<-apo[,1]
apo<-apo[,-1]
apo<-apo+1
lRctl<-log(apo[,c(seq(2,16,2))],2)-log(apo[,c(seq(1,15,2))],2)
lRtxt<-log(apo[,c(seq(18,32,2))],2)-log(apo[,c(seq(17,31,2))],2)
lIctl<-log(apo[,c(seq(2,16,2))],2)+log(apo[,c(seq(1,15,2))],2)
lItxt<-log(apo[,c(seq(18,32,2))],2)+log(apo[,c(seq(17,31,2))],2)
lRnorm<-norm2c(lRctl,lRtxt,lIctl,lItxt)
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注：
注1：为了方便大家学习，本文档为生物统计家园网机器人LoveR翻译而成，仅供个人R语言学习参考使用，生物统计家园保留版权。
注2：由于是机器人自动翻译，难免有不准确之处，使用时仔细对照中、英文内容进行反复理解，可以帮助R语言的学习。
注3：如遇到不准确之处，请在本贴的后面进行回帖，我们会逐渐进行修订。
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发表于 2012-2-26 07:57:07
