norm1a(nudge)
norm1a()所属R语言包:nudge
Function for normalizing the mean of single replicate log ratios
平均单复制log比率标准化的功能
译者:生物统计家园网 机器人LoveR
描述----------Description----------
This is essentially the same as the lowess normalization suggested in the paper "Statistical methods for identifying differentially expressed genes in replicated cDNA microarrays" by Dudoit et al (2002), except the loess function is used instead of lowess and the recommended span is between 0.6 and 0.8. The normalization is done for each gene by subtracting from its log ratio the loess estimated mean for the log ratio based on the regression of log ratios on log intensities.
这实质上是作为纸张等Dudoit(2002)“确定在复制的基因芯片差异表达基因的统计方法”中提出的LOWESS标准化一样,除了黄土的功能是用来代替的LOWESS推荐跨度之间0.6和0.8。每个基因减去其log比黄土估计指的loglog强度的比率回归的log比标准化。
用法----------Usage----------
norm1a(logratio, logintensity, span = 0.6)
参数----------Arguments----------
参数:logratio
A vector or single-column matrix of log (base 2) ratios of gene expressions in two samples.
的log矩阵向量或单柱(基数为2)两个样本中的基因表达比例。
参数:logintensity
A vector or single-column matrix of log (base 2) total intensities (defined as the product) of gene expressions in the two samples.
矩阵向量或单柱的log总强度(基2)两个样本中的基因表达(定义为产品)。
参数:span
Proportion of data used to fit the loess regression of the log ratios on the log intensities.
适合黄土的对log强度的log比回归用于数据的比例。
值----------Value----------
A vector or single-column matrix of mean normalized log ratios.
一个平均归log比矩阵向量或单柱。
作者(S)----------Author(s)----------
N. Dean and A. E. Raftery
参考文献----------References----------
参见----------See Also----------
norm1b,norm1c,norm1d,norm2c,norm2d
norm1b,norm1c,norm1d,norm2c,norm2d
举例----------Examples----------
data(like)
lR<-log(like[,1],2)-log(like[,2],2)
lI<-log(like[,1],2)+log(like[,2],2)
lRnorm<-norm1a(lR,lI)
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
注1:为了方便大家学习,本文档为生物统计家园网机器人LoveR翻译而成,仅供个人R语言学习参考使用,生物统计家园保留版权。
注2:由于是机器人自动翻译,难免有不准确之处,使用时仔细对照中、英文内容进行反复理解,可以帮助R语言的学习。
注3:如遇到不准确之处,请在本贴的后面进行回帖,我们会逐渐进行修订。
|