GWASTools-package(GWASTools)
GWASTools-package()所属R语言包：GWASTools
Tools for Genome Wide Association Studies
全基因组关联研究的工具
译者：生物统计家园网 机器人LoveR
描述----------Description----------
This package contains tools for facilitating cleaning (quality control and quality assurance) and analysis of GWAS data.
该软件包包含用于促进清洁（质量控制和质量保证）的GWAS数据分析的工具。
Details
详情----------Details----------
GWASTools provides a set of classes for storing data and annotation from Genome Wide Association studies, and a set of functions for data cleaning and analysis that operate on those classes.
GWASTools提供了一套用于存储数据和注释从全基因组关联研究类，一组数据清洗和分析的功能，对这些类的操作。
Genotype and intensity data are stored in NetCDF files, so it is possible to analyze data sets that are too large to be contained in memory. The NcdfReader class provides a generic interface to the NetCDF files (utilizing the ncdf package), and the NcdfGenotypeReader and NcdfIntensityReader classes provide specific methods to access genotype and intensity data.
基因型频率和强度的数据存储在NetCDF文件，所以分析是太大，无法在内存中的数据集，是有可能的。类提供NcdfReader一个通用的接口NetCDF文件（利用ncdf包），NcdfGenotypeReader和NcdfIntensityReader类提供具体的方法来访问基因型和强度数据。
Two sets of classes for annotation are provided. SnpAnnotationDataFrame and ScanAnnotationDataFrame extend AnnotatedDataFrame and provide in-memory containers for SNP and scan annotation and metadata. SnpAnnotationSQLite and ScanAnnotationSQLite provide interfaces to SNP and scan annotation and metadata stored in SQLite databases.
提供两套注释的类。 SnpAnnotationDataFrame和ScanAnnotationDataFrame延长AnnotatedDataFrame“提供内存中的SNP和扫描注释和元容器。 SnpAnnotationSQLite和ScanAnnotationSQLite提供SNP和扫描注释和元数据存储在SQLite数据库中的接口。
The GenotypeData and IntensityData classes combine genotype or intensity data with SNP and scan annotation, ensuring that the data in the NetCDF files is consistent with annotation through unique SNP and scan IDs. A majority of the functions in the GWASTools package take GenotypeData and/or IntensityData objects as arguments.
GenotypeData和IntensityData类结合基因型或强度与SNP和扫描注释数据，确保在NetCDF文件的数据是通过独特的SNP和扫描标识标注一致。大部分功能在GWASTools包GenotypeData和/或IntensityData作为参数的对象。
作者（S）----------Author(s)----------
Stephanie Gogarten, Cathy Laurie, Tushar Bhangale, Matt Conomos, Cecilia Laurie, Caitlin McHugh, Ian Painter, Xiuwen Zheng, Rohit Swarnkar
Maintainer: Stephanie Gogarten <a href="mailto:sdmorris@u.washington.edu">sdmorris@u.washington.edu</a>
参考文献----------References----------
Bhangale, T., Boehm, F., Caporaso, N. E., Cornelis, M. C., Edenberg, H. J., Gabriel, S. B., Harris, E. L., Hu, F. B., Jacobs, K. B., Kraft, P., Landi, M. T., Lumley, T., Manolio, T. A., McHugh, C., Painter, I., Paschall, J., Rice, J. P., Rice, K. M., Zheng, X., and Weir, B. S., for the GENEVA Investigators (2010), Quality control and quality assurance in genotypic data for genome-wide association studies. Genetic Epidemiology, 34: 591-602. doi: 10.1002/gepi.20516
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注：
注1：为了方便大家学习，本文档为生物统计家园网机器人LoveR翻译而成，仅供个人R语言学习参考使用，生物统计家园保留版权。
注2：由于是机器人自动翻译，难免有不准确之处，使用时仔细对照中、英文内容进行反复理解，可以帮助R语言的学习。
注3：如遇到不准确之处，请在本贴的后面进行回帖，我们会逐渐进行修订。
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发表于 2012-2-25 21:24:16
