simulateModule(WGCNA)
simulateModule()所属R语言包：WGCNA
Simulate a gene co-expression module
模拟基因共表达模块。
译者：生物统计家园网 机器人LoveR
描述----------Description----------
Simulation of a single gene co-expression module.
一个单一的基因共表达模块仿真。
用法----------Usage----------
simulateModule(
ME,
nGenes,
nNearGenes = 0,
minCor = 0.3, maxCor = 1, corPower = 1,
signed = FALSE, propNegativeCor = 0.3,
geneMeans = NULL,
verbose = 0, indent = 0)
参数----------Arguments----------
参数：ME
seed module eigengene.
种子模块eigengene。
参数：nGenes
number of genes in the module to be simulated. Must be non-zero.
模块是模拟的基因数目。必须是非零。
参数：nNearGenes
number of genes to be simulated with low correlation with the seed eigengene.
数目的基因，是具有低相关性的种子eigengene模拟。
参数：minCor
minimum correlation of module genes with the eigengene. See details.
最小相关基因与eigengene模块。查看详细信息。
参数：maxCor
maximum correlation of module genes with the eigengene. See details.
最大相关模块基因与eigengene。查看详细信息。
参数：corPower
controls the dropoff of gene-eigengene correlation. See details.
控制空投基因eigengene相关。查看详细信息。
参数：signed
logical: should the genes be simulated as belonging to a signed network? If TRUE, all genes will be simulated to have positive correlation with the eigengene. If FALSE, a proportion given by propNegativeCor will be simulated with negative correlations of the same absolute values.
逻辑的基因签署的网络模拟？如果TRUE，所有基因将模拟的有正相关的eigengene的。如果FALSE，由propNegativeCor的比例将相同的绝对值呈负相关的模拟。
参数：propNegativeCor
proportion of genes to be simulated with negative gene-eigengene correlations. Only effective if signed is FALSE.
的基因的比例是模拟具有负的基因eigengene相关的。只有有效的，如果signed是FALSE。
参数：geneMeans
optional vector of length nGenes giving desired mean expression for each gene. If not given, the returned expression profiles will have mean zero.
可选的矢量的长度nGenes给需要的平均每个基因的表达。如果没有给出，返回的表达谱具有均值为零。
参数：verbose
integer level of verbosity. Zero means silent, higher values make the output progressively more and more verbose.
整数的详细程度。零表示沉默，较高的值使输出越来越多，更详细。
参数：indent
indentation for diagnostic messages. Zero means no indentation, each unit adds two spaces.
缩进诊断消息。零表示无压痕，每个单元增加两个空格。
Details
详细信息----------Details----------
Module genes are simulated around the eigengene by choosing them such that their (expected) correlations with the seed eigengene decrease progressively from (just below) maxCor to minCor. The genes are otherwise independent from one another. The variable corPower determines how fast the correlation drops towards minCor. Higher powers lead to a faster frop-off; corPower must be above zero but need not be integer.
模块基因是模拟周围eigengene选择他们，这样他们（预期）的相关性与种子eigengene递减（正下方）maxCorminCor。该基因是另有彼此独立。变量corPower决定向minCor的相关性下降的速度有多快。更高的权力导致更快的frop过，“corPower必须大于零，但不必是整数。
If signed is FALSE, the genes are simulated so as to be part of an unsigned network module, that is some genes will be simulated with a negative correlation with the seed eigengene (but of the same absolute value that a positively correlated gene would be simulated with). The proportion of genes with negative correlation is controlled by propNegativeCor.
如果signed是FALSE模拟，基因是一个无符号的网络模块，从而成为其中的一部分，这是某些基因将模拟的种子eigengene呈负相关（但相同的绝对值呈极显着正相关的基因，将模拟）。的比例呈负相关的基因所控制propNegativeCor。
Optionally, the function can also simulate genes that are "near" the module, meaning they are simulated with a low but non-zero correlation with the seed eigengene. The correlations run between minCor and zero.
任选地，还可以模拟功能的基因，是“近”的模块，这意味着它们是模拟低但非零的相关性与种子eigengene。运行minCor和零之间的相关性。
值----------Value----------
A matrix containing the expression data with rows corresponding to samples and columns to genes.
含A矩阵的行对应的样品和列的基因的表达数据。
（作者）----------Author(s)----------
Peter Langfelder
参考文献----------References----------
to the article
modules. BMC Systems Biology 2007, 1:54.
http://www.genetics.ucla.edu/labs/horvath/CoexpressionNetwork/EigengeneNetwork/SupplementSimulations.pdf.
参见----------See Also----------
simulateEigengeneNetwork for a simulation of eigengenes with a given causal structure;
simulateEigengeneNetwork的模拟与给定的因果结构的特征基因;
simulateDatExpr for simulations of whole datasets consisting of multiple modules;
simulateDatExpr整个数据集由多个模块组成的模拟;
simulateDatExpr5Modules for a simplified interface to expression simulations;
simulateDatExpr5Modules的简化表达模拟接口;
simulateMultiExpr for a simulation of several related data sets.
simulateMultiExpr一个模拟的几个相关的数据集。
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注：
注1：为了方便大家学习，本文档为生物统计家园网机器人LoveR翻译而成，仅供个人R语言学习参考使用，生物统计家园保留版权。
注2：由于是机器人自动翻译，难免有不准确之处，使用时仔细对照中、英文内容进行反复理解，可以帮助R语言的学习。
注3：如遇到不准确之处，请在本贴的后面进行回帖，我们会逐渐进行修订。
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发表于 2012-10-1 22:22:01
