normalizeWithinSamples(charm)
normalizeWithinSamples()所属R语言包:charm
Within-sample normalization for two-color data
样本内两色数据的标准化
译者:生物统计家园网 机器人LoveR
描述----------Description----------
Within-sample (between-channel) normalization for two-color DNA methylation microarray data. This function implements the control probe loess procedure described in Aryee et al., 2011 (PMID: 20858772).
样本内(之间的通道)两色的DNA甲基化微阵列数据的标准化。此功能实现Aryee等,2011(关键词:20858772)。控制探针黄土过程。
用法----------Usage----------
normalizeWithinSamples(dat, copy=TRUE,
method = "loess", scale=c(0.99, 0.99),
controlProbes = NULL, controlIndex = NULL, approx=TRUE, breaks=1000, verbose=FALSE)
参数----------Arguments----------
参数:dat
a TilingFeatureSet
1 TilingFeatureSet
参数:copy
Only relevant when using disk-backed objects. If TRUE a copy will be made leaving the original object (dat) unchanged. The input object will not be preserved if copy=FALSE
只有相关时使用的磁盘备份的对象。如果是TRUE副本将离开原来的对象(DAT)不变。输入对象将不会被保留,如果复制= FALSE
参数:method
normalization method. "loess" or "none"
归一化方法。 “黄土”或“无”
参数:scale
a numeric vector (x,y). The xth percentile of each sample is scaled to represent y% methylation. The default c(0.99, 0.99) means probes in the 99% percentile represent 99% methylation. Set to NA for no scaling.
一个数值向量(X,Y)。每个样品的第十届百分缩放代表同期甲基化。默认的C(0.99,0.99),是指探针在99%百分位代表99%的甲基化。设置为NA不结垢。
参数:controlProbes
character string of the label assigned to non-CpG control probes in the annotation file (i.e. the container column of the .ndf file).
分配给非的CpG控制探针在注释文件(即货柜列。NDF文件)的标签的字符串。
参数:controlIndex
a vector of non-CpG control probe indices
一个非CPG控制探针指数的向量
参数:approx
Bin probes by signal intensity when loess normalizing. Much faster when TRUE
黄土标准化时的信号强度斌探针。快得多当为true
参数:breaks
Number of bins to use when approx=TRUE
时使用的箱数约= TRUE
参数:verbose
boolean: Verbose output?
布尔:详细输出?
Details
详情----------Details----------
This function is used by methp performs within-sample (between-channel) normalization. It is normally not used directly by the user.
此功能用于methp执行样本内(之间的通道)标准化。它通常是用户不能直接使用。
值----------Value----------
a TilingFeatureSet
1 TilingFeatureSet
作者(S)----------Author(s)----------
Martin Aryee <aryee@jhu.edu>, Rafael Irizarry
举例----------Examples----------
# See normalizeBetweenSamples[看到normalizeBetweenSamples]
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
注1:为了方便大家学习,本文档为生物统计家园网机器人LoveR翻译而成,仅供个人R语言学习参考使用,生物统计家园保留版权。
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