Routines for the functional analysis of biological networks
例程生物网络的功能分析
译者:生物统计家园网 机器人LoveR
描述----------Description----------
This package provides functions for the integrated analysis of biological networks and the detection of functional modules. Different datasets can be integrated into the network by assigning p-values derived from statistical tests to the nodes of the network. E.g. p-values obtained from the differential expression of genes from an Affymetrix array are assigned to the nodes of an protein-protein interaction network. By fitting a beta-uniform mixture model and calculating scores from the p-values, overall scores of network regions can be calculated and an integer linear programming algorithm identifies the maximum scoring subnetwork.
这个软件包提供的生物网络的综合分析和检测功能模块的功能。从统计检验的网络节点分配的p值,不同的数据可以集成到网络。例如从Affymetrix公司的阵列基因表达差异,得到的P-值被分配到一个蛋白质相互作用网络的节点。装修β-均匀混合模型和从P-值计算分数,可以计算和网络区域的整体分数,整数线性规划算法标识子网的最高得分。
Details
详情----------Details----------
作者(S)----------Author(s)----------
Marcus Dittrich, Daniela Beisser
Maintainer: Marcus Dittrich <marcus.dittrich@biozentrum.uni-wuerzburg.de>