filter.wellaboveBG(Agi4x44PreProcess)
filter.wellaboveBG()所属R语言包：Agi4x44PreProcess
probes.filter (Internal function)
probes.filter（内部函数）
译者：生物统计家园网 机器人LoveR
描述----------Description----------
An internal function to be used by filter.probes
一个内部函数filter.probes
用法----------Usage----------
filter.wellaboveBG(ddFILT, limWellAbove, ManuelaGO, targets, annotation.package)
参数----------Arguments----------
参数：ddFILT
an RGlist object
RGlist对象
参数：limWellAbove
for a given feature xi accros samples, is the minimum in an experimental condition with a wellaboveBG-FLAG = 1 (Is Well Above BG)
对于一个给定的功能第十一accros样品，至少是在实验条件与wellaboveBG旗= 1（远高于BG是）
参数：ManuelaGO
logical, if a known annotation package is available then it is TRUE
逻辑，如果一个已知的注解包是可用的，那么它是TRUE
参数：targets
data.frame with the target structure
数据框与目标结构
参数：annotation.package
a character specifying the AGI annotation package: 'hgug4112a.db','mgug4122a.db'
一个字符指定的AGI注解包：“hgug4112a.db，mgug4122a.db”
Details
详情----------Details----------
It eliminates signals that were not distinguishable from the local background signal. The filtering is based on the FLAG given by the AFE as follows: For a feature = xi accross all the samples, we demand that at least p spots for that feature, in at least one experimental condition, had a quantification flag denoting that the signal is distinguishable from background. AFE produces a Boolean flag indicating if a spot is WellAbove Background (Flag = 1) or not (Flag = 0). A spot reaches a Flag = 1 if IsPosAndSignif and additionally the gBGSubSignal is greater than 2.6*g(r)BG\_SD. IsPosAndSignif uses a Boolean flag, established via a 2-sided t-test, indicates if the mean signal of a spot is greater than the corresponding background. 1 indicates spot is positive and significant above background.
它消除了不从当地的背景信号分辨的信号。 AFE的如下标志：根据过滤功能=第十一accross所有样品，我们要求至少该功能的P点，至少在一个实验条件下，有量化标志表示该信号是从后台的区别。 AFE产生一个布尔标志，表示如果当场WellAbove背景（旗= 1）或（标志= 0）。 A点到达一个标志= 1，如果IsPosAndSignif和另外gBGSubSignal的是超过260克（R）BG \ _SD。 IsPosAndSignif成立，通过双面t检验使用一个布尔标志，表示如果一个点的平均信号大于相应的背景。 1点是积极的，上述背景下具有重要意义。
值----------Value----------
An RGlist with probes that are above BG (according to the correspondind AFE flag and the filtering options). It also writes an output file (IsNOTWellAboveBG.txt) that contains the probes that were filtered out because they were not distinguishable from the local background signal.
与探针上述保函（根据correspondind AFE的标志和过滤选项）RGlist。它也写到一个输出文件（IsNOTWellAboveBG.txt）包含被过滤掉，因为他们没有区别的，从当地的背景信号的探针。
作者（S）----------Author(s)----------
Pedro Lopez-Romero
参见----------See Also----------
filter.probes
filter.probes
举例----------Examples----------
## Not run: [＃无法运行：]
data(dd)
data(targets)
library(hgug4112a.db)
ddFILT=filter.wellaboveBG(dd,75,TRUE,targets,"hgug4112a.db")
dim(ddFILT)
## End(Not run)[＃结束（不运行）]
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注：
注1：为了方便大家学习，本文档为生物统计家园网机器人LoveR翻译而成，仅供个人R语言学习参考使用，生物统计家园保留版权。
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发表于 2012-2-25 11:34:29
