Five rabbits were studied on two occasions, after treatment with saline (control) and after treatment with the 5-HT_3 antagonist MDL 72222. After each treatment ascending doses of phenylbiguanide were injected intravenously at 10 minute intervals and the responses of mean blood pressure measured. The goal was to test whether the cardiogenic chemoreflex elicited by phenylbiguanide depends on the activation of 5-HT_3 receptors.
两次五兔进行了研究后,用生理盐水(对照组)的治疗和治疗后5-HT_3拮抗剂的MDL 72222。每次治疗后升苯基双胍剂量静脉注射,每隔10分钟测量平均血压的反应。我们的目标是测试是否苯基双胍引起的心源性化学感受性反射取决于5-HT_3受体的激活。
用法----------Usage----------
Rabbit
格式----------Format----------
This data frame contains 60 rows and the following variables:
此数据框包含60行和以下变量:
change in blood pressure relative to the start of the experiment.
在血压相对实验开始改变。
dose of Phenylbiguanide in micrograms.
剂量微克苯基双胍。
label of run ("C1" to "C5", then "M1" to "M5").
运行标签("C1""C5","M1""M5"的)。
placebo or the 5-HT_3 antagonist MDL 72222.
安慰剂或5-HT_3拮抗剂的MDL 72222。
label of animal used ("R1" to "R5").
动物标签("R1""R5")。
源----------Source----------
J. Ludbrook (1994) Repeated measurements and multiple comparisons in cardiovascular research. Cardiovascular Research 28, 303–311.<br> [The numerical data are not in the paper but were supplied by Professor Ludbrook]
J. Ludbrook(1994)重复测量和心血管研究中的多重比较。 [心血管病研究所28,303-311。参考数值数据的文件,但不教授Ludbrook提供]
参考文献----------References----------
Modern Applied Statistics with S. Fourth edition. Springer.
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。