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The common disease, common variant approach of genome-wide association studies has yielded a few variants of modest effect size for glaucoma, which is the most common cause of irreversible blindness in the world. Much of the heritability is still “missing”. We propose to use a next generation sequencing approach to examine rare variants with potentially larger effect size. The PhD student will have access to a unique sample of 2,400 subjects from the TwinsUK cohort who will have had whole-genome sequencing as part of the 10,000 Genomes Project, and who have glaucoma assessments. Analysis will be performed using methods developed in conjunction with the Wellcome Trust Sanger Centre, such as pooling rare variants to create “super loci”. Replication of identified loci will be performed on a group of glaucoma cases and controls collected separately. The PhD student will acquire cutting-edge skills in genetic statistics and analysis, and will be fully supported by trained genetic statisticians. Applications are welcomed from numerate students with degrees in genetics, biostatistics, mathematics and epidemiology.
Funding Notes:
The Studentship is open to UK & EU candidates. The funding also covers tuition fees at the EU (Home) rate. Applications from outside the EU are welcome provided candidates can source funding to cover the overseas fees.
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发表于 2011-5-1 10:55:20