empiricalStart(XDE)
empiricalStart()所属R语言包:XDE
Empirical starting values for the MCMC
实证出发值的MCMC
译者:生物统计家园网 机器人LoveR
描述----------Description----------
Empirical starting values for the MCMC are based on data in objects of class ExpressionSetList
实证出发的MCMC值是基于数据类对象ExpressionSetList
用法----------Usage----------
empiricalStart(object, zeroNu = FALSE, phenotypeLabel, one.delta=FALSE, T_THRESH=4)
参数----------Arguments----------
参数:object
An object of class ExpressionSetList
一个对象的类ExpressionSetList
参数:zeroNu
Logical: if TRUE, the nu in the Bayesian model are not modeled – set to zero and not updated in the MCMC. Setting zeroNu to TRUE should be regarded as experimental
逻辑:如果为TRUE,在贝叶斯模型的怒江建模 - 设置为零,并在没有更新的MCMC。将zeroNu设置为TRUE,应被视为实验
参数:phenotypeLabel
character: binary phenotype. phenotypeLabel must be in the varLabels of each ExpressionSet object
字符:二进制型。 phenotypeLabel必须在每个ExpressionSet对象的varLabels
参数:one.delta
delta in the Bayesian model is a gene-specific indicator for differential expression. If one.delta is FALSE, we assume that a gene can be differentially expressed in a subset of studies. When TRUE, we assume that a gene is differentially expressed in all studies or in none.
Delta是在贝叶斯模型的差异表达基因的具体指标。如果one.delta是FALSE,我们假设,一个基因可以在研究的一个子集差异表达。 TRUE时,我们假设,在所有研究或没有表达的基因差异。
参数:T_THRESH
A threshold of t-statistics (calculated row-wise for each study) for determining starting values of the differential expression indicator, delta.
t-统计(计算每个研究逐行)确定初始值的差异表达的指标,Delta的一个阈值。
值----------Value----------
A list containing starting values for the MCMC that are derived from empirical estimates of the data.
一个列表,其中包含的MCMC方法,从数据的实证估计所得的初始值。
作者(S)----------Author(s)----------
R. Scharpf
参见----------See Also----------
zeroNu, XdeParameter-class,
zeroNu,XdeParameter-class
举例----------Examples----------
library(XDE)
data(expressionSetList)
eList <- studyCenter(expressionSetList)
empirical <- empiricalStart(eList, phenotypeLabel="adenoVsquamous", T_THRESH=3)
##By default, initial values for the MCMC are sampled from the prior[#默认情况下,初始值的MCMC采样前]
##when initializing an object of class XdeParamater[#当初始化类XdeParamater的对象]
params <- new("XdeParameter", esetList=eList,
phenotypeLabel="adenoVsquamous", one.delta=FALSE, burnin=TRUE)
##The initial values can be replaced by empirical values as follows:[#初始值可以取代经验值如下:]
firstMcmc(params) <- empirical
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
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