nem.discretize(nem)
nem.discretize()所属R语言包:nem
Discretize perturbation data according to control experiments
离散扰动数据,根据对照实验
译者:生物统计家园网 机器人LoveR
描述----------Description----------
discretizes raw data to define effects of interventions with respect to wildtype/control measurements
离散原始数据定义与野生型/控制测量方面的干预效果
用法----------Usage----------
nem.discretize(D,neg.control=NULL,pos.control=NULL,nfold=2,cutoff=0:10/10, pCounts=20, empPval=.05, verbose=TRUE)
参数----------Arguments----------
参数:D
matrix with experiments as columns and effect reporters as rows
矩阵与列和行的效果记者实验
参数:neg.control
either indices of columns in D or a matrix with the same number of rows as D
D或与相同数量的行D的矩阵列任指数
参数:pos.control
either indices of columns in D or a matrix with the same number of rows as D
D或与相同数量的行D的矩阵列任指数
参数:nfold
fold-change between neg. and pos. controls for selecting effect reporters. Default: 2
倍之间的负变化。和POS。选择的影响记者的控制。默认是:2
参数:cutoff
a (vector of) cutoff value(s) weighting the pos. controls versus the neg. controls. Default: 0:10/10
(矢量)的临界值(S)的比重在POS。与NEG的控制。控制。默认:0:10 / 10
参数:pCounts
pseudo-counts to guard against unreasonable low error estimates
伪计数,以防止不合理的低错误估计
参数:empPval
empirical p-value cutoff for effects if only one control is available
经验p值截止的影响,如果只有一个控制
参数:verbose
Default: TRUE
默认:true
Details
详情----------Details----------
Chooses cutoff such that separation between negative and positive controls becomes optimal.
阴性和阳性对照组之间的分离成为最佳选择截止。
值----------Value----------
参数:dat
discretized data matrix
离散数据矩阵
参数:pos
discretized positive controls [in the two-controls setting]
离散阳性对照[在两个控件设置]
参数:neg
discretized negative controls [in the two-controls setting]
离散阴性对照[在两个控件设置]
参数:sel
effect reporters selected [in the two-controls setting]
选择效果记者在两个控件设置]
参数:cutoff
error rates for different cutoff values [in the two-controls setting]
在两个控件设置不同的临界值的误差率[]
参数:para
estimated error rates [in the two-controls setting]
估计错误率[在两个控件设置]
注意----------Note----------
preliminary! will be developed to be more generally applicable
初步的!将发展成为更普遍适用
作者(S)----------Author(s)----------
Florian Markowetz <URL: http://genomics.princeton.edu/~florian>
参考文献----------References----------
<h3>See Also</h3>
举例----------Examples----------
# discretize Boutros data as in[在离散布特罗斯数据]
# Markowetz et al, 2005[markowetz等,2005]
data("BoutrosRNAi2002")
disc <- nem.discretize(BoutrosRNAiExpression,neg.control=1:4,pos.control=5:8,cutoff=.7)
stopifnot(disc$dat==BoutrosRNAiDiscrete[,9:16])
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
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