duplicateDiscordanceProbability(GWASTools)
duplicateDiscordanceProbability()所属R语言包:GWASTools
Probability of duplicate discordance
重复不一致的概率
译者:生物统计家园网 机器人LoveR
描述----------Description----------
duplicateDiscordanceProbability calculates the probability of observing discordant genotypes for duplicate samples.
duplicateDiscordanceProbability计算观察不和谐的重复样本的基因型的概率。
用法----------Usage----------
duplicateDiscordanceProbability(npair,
error.rate = c(1e-5, 1e-4, 1e-3, 1e-2),
max.disc = 7)
参数----------Arguments----------
参数:npair
The number of pairs of duplicate samples.
对重复样本数。
参数:error.rate
A numeric vector of error rates (i.e., the rate at which a genotype will be called incorrectly).
一个错误率的数字矢量(即,将被称为基因型错误率)。
参数:max.disc
The maximum number of discordances for which to compute the probability.
的不一致性计算的概率最大数量。
Details
详情----------Details----------
Since there are three possible genotypes, one call is correct and the other two are erroneous, so theoretically there are two error rates, a and b. The probability that duplicate genotyping instances of the same subject will give a discordant genotype is 2[(1 - a - b)(a + b) + ab]. When a and b are very small, this is approximately 2(a + b) or twice the total error rate. This function assumes that a == b, and the argument error.rate is the total error rate a + b.
由于有三种可能的基因型,一次通话是正确的,其他两个是错误的,所以理论上有两种错误率,A和B。同一主题的重复基因分型情况下,会给一个不和谐的基因型的概率是2 [(1 - A - B)(A + B)+ AB]。当A和B都非常小,这大约是2(A + B)或两次总的错误率。这个函数假设,== B,参数error.rate是总误差率A + B。
值----------Value----------
This function returns a matrix of probabilities, where the column names are error rates and the row names are expected number of discordant genotypes (>0 through >max.disc).
这个函数返回的概率矩阵,列名其中的错误率和行名,预计一些不和谐的基因型(> 0,通过>max.disc)。
作者(S)----------Author(s)----------
Cathy Laurie
参见----------See Also----------
duplicateDiscordance,
duplicateDiscordance
举例----------Examples----------
disc <- duplicateDiscordanceProbability(npair=10, error.rate=c(1e-6, 1e-4))
#probability of observing >0 discordant genotypes given an error rate 1e-6[观察> 0不和谐的基因型错误率1E-6的概率]
disc[1,1]
#probability of observing >1 discordant genotypes given an error rate 1e-4[观察> 1不和谐的基因型错误率1E-4的概率]
disc[2,2]
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
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