LinearNet(GRENITS)
LinearNet()所属R语言包:GRENITS
Dynamic Bayesian Network Inference Using Linear Interactions
使用非线性相互作用的动态贝叶斯网络推理
译者:生物统计家园网 机器人LoveR
描述----------Description----------
Run Bayesian inference of linear interaction network. The function generates MCMC chains that can later be analysed.
线性相互作用网络运行的贝叶斯推断。函数生成的MCMC链,可以在以后进行分析。
用法----------Usage----------
LinearNet( resultsFolder, timeSeries, ParamVec = NULL,
chains = 2, user.seeds = NULL, Regulators = NULL,
fixMe = NULL)
参数----------Arguments----------
参数:resultsFolder
Name of output folder. The folder will be created and the output of the run will be placed there.
输出文件夹的名称。该文件夹将创建和运行的输出将被放置在那里。
参数:timeSeries
Data matrix containing gene expression time series. Where genes will be placed in rows and time points in columns. Gene names may be included as row names.
含有基因表达的时间序列数据矩阵。基因将被放置行和列的时间点。基因名称可能被列为行名称。
参数:ParamVec
A parameter vector created using "mcmc.defaultParams_Linear". If none is given, default parameters will be used. The vector contains parameters associated to the priors as well as MCMC run length. (See mcmc.defaultParams_Linear)
创建一个参数向量使用“mcmc.defaultParams_Linear”。如果没有给出,默认参数将被使用。矢量包含相关的先验以及MCMC稳态运行长度的参数。 (见mcmc.defaultParams_Linear)
参数:chains
Number of MCMC chains to run.
MCMC方法链运行的数量。
参数:user.seeds
An optional vector with seeds to use for MCMC chains.
一个可选的向量,与种子使用的MCMC链。
参数:Regulators
An optional vector with the indices of which genes are regulators. If provided, all non-regulator genes will not be allowed to regulate.
哪些基因是监管与指数的一个可选的向量。如果提供的话,将不会被允许所有非调节基因的调节。
参数:fixMe
An optional matrix of size genes x genes, where columns represent regulators and rows regulated genes. The matrix informs the model of network connections known to be present/absent. For each position use either 0 (no regulation, fix off), 1 (known regulatory interaction, fix on) or NaN (no information, do not fix).
可选的大小基因矩阵X基因,列代表监管和调控的基因行。矩阵通知已知出席/缺席的网络连接模式。每个位置使用的是0(没有监管,解决关闭),1(已知的监管互动,修复)或NaN(没有信息,不固定)。
值----------Value----------
For each chain run, a folder (chain1, chain2, ...) will be created and the output of the MCMC run will be placed there. The files will be B_mcmc (the coeffcients of the linear regression), Gamma_mcmc (the indicator variables of Gibbs variable selection), Lambda_mcmc (the precision of each regression), Mu_mcmc (the intercept of each regression) and Rho_mcmc (the network connectivity parameter).
对于每一个链的运行,一个文件夹(chain1 1,chain2,...)将创建和输出的MCMC运行将放在那里。该文件将被B_mcmc(线性回归系数的),Gamma_mcmc(吉布斯变量选择的指标变量),Lambda_mcmc(每个回归的精度),Mu_mcmc(每个回归截距)和Rho_mcmc(网络连接参数) 。
参考文献----------References----------
networks using time course data with repeated measurements. Bioinformatics 2010; doi: 10.1093/bioinformatics/btq421
topology of a nonlinear sparse gene regulatory network using fully Bayesian spline autoregression Biostatistics 2011; doi: 10.1093/biostatistics/kxr009
参见----------See Also----------
mcmc.defaultParams_Linear, analyse.output.
mcmc.defaultParams_Linear, analyse.output。
举例----------Examples----------
# Load A. thaliana circadian clock ODE generated data[生成的数据负载拟南芥生物钟的ODE]
data(Athaliana_ODE)
# Folder where raw runs will be kept and analysed[原料运行文件夹中,将保留和分析]
output.folder <- paste(tempdir(), "/Example_LinearNet",sep="")
# Run network inference, place raw results in output.folder[运行网络推断,原始结果将在output.folder]
LinearNet(output.folder, Athaliana_ODE)
# Analyse raw results, place analysis plots and files in output.folder[分析原料的结果,地方分析图和文件,在output.folder]
analyse.output(output.folder)
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
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