Treating for glocal redundancy between GO terms which share multiple function genes but have no ancient-offspring relationship
共享多个功能基因的GO术语之间的全球本土化冗余治疗，但没有古代的后代关系
译者：生物统计家园网 机器人LoveR
描述----------Description----------
For a pair of terms with overlapping genes, this function can identify whether their significance might be simply introduced by the overlapping genes (see details).
对于一对重叠基因，此功能可以识别其意义是否可以简单介绍了重叠基因（见详情）。
参数----------Arguments----------
参数：generalAnn
generalAnn is the mapping between gene and GO terms.
generalAnn是基因和GO术语之间的映射。
参数：sigTermRelation
sigTermRelation is the GO DAG relationship between the statistically significant terms.
sigTermRelation是GO的DAG统计学意义之间的关系。
参数：annRef
annRef is the annotated reference genes and their annotated terms.
annRef注释参考基因及其注释的条款。
参数：annInterest
annInterest is the annotated interesting genes and their annotated terms.
annInterest注明有趣的基因，并注明条款。
参数：sigTermRedun
sigTermRedun is the remained statistically signifcant terms after treating local redundancy.
sigTermRedun是维持治疗后，本地冗余统计显着性条款。
参数：poth
poth is the significant level to test whether the overlapping genes of one term is significantly different from the non-overlapping genes of the term. The default is 0.05.
poth是显着的水平，以测试是否一个术语的重叠基因是从术语的非重叠基因显着不同。默认是0.05。
参数：peth
peth is the significant level to test whether the non-overlapping genes of one term is enriched with interesting genes. The default is 0.05.
peth是显着的水平，以测试是否一个术语的非重叠基因是丰富有趣的基因。默认是0.05。
Details
详情----------Details----------
This function uses the following principles to treat for glocal redundancy between GO terms which share multiple function genes but have no ancient-offspring relationship. For a pair of overlapping terms, GO-function remains one term only if (1) there is additional evidence that the non-overlapping genes of a term may be related to the disease if the frequency of interesting genes in these genes is not significantly different from that in the overlapping genes or is significantly higher than the random background; and (2) there is no such evidence for the non-overlapping genes of another term. In all the other situations, GO-function remains both terms.
此函数使用以下原则对待全球本土化冗余之间共享多个功能基因，但没有古代的后代关系的GO术语。一对重叠的条款，GO功能仍然只有一个任期（1）有更多的证据，一个术语的非重叠基因可能有关的疾病，如果在有趣的基因，这些基因的频率是不显着不同从重叠基因或明显比随机背景;（2）另一个术语的非重叠的基因有没有这样的证据。 GO功能在所有其他情况下，仍然是这两个方面。
值----------Value----------
The function returns a set of remained terms with evidence that their significance should not be simply due to the overlapping genes.
该函数返回的证据表明，其意义不应该只是由于重叠基因仍然条款。
发表于 2012-2-25 20:46:39
