subtype.cluster.predict(genefu)
subtype.cluster.predict()所属R语言包:genefu
Function to identify breast cancer molecular subtypes using the Subtype Clustering Model
功能识别乳腺癌分子亚型使用亚型聚类模型
译者:生物统计家园网 机器人LoveR
描述----------Description----------
This function identifies the breast cancer molecular subtypes using a Subtype Clustering Model fitted by subtype.cluster.
此功能可识别乳腺癌安装subtype.cluster使用子类型的聚类分析模型的分子亚型。
用法----------Usage----------
subtype.cluster.predict(sbt.model, data, annot, do.mapping = FALSE,
mapping, do.prediction.strength = FALSE,
do.BIC = FALSE, plot = FALSE, verbose = FALSE)
参数----------Arguments----------
参数:sbt.model
Subtype Clustering Model as returned by subtype.cluster.
亚型和聚类分析模型返回subtype.cluster的。
参数:data
Matrix of gene expressions with samples in rows and probes in columns, dimnames being properly defined.
矩阵中的行和列的探针样品的基因表达,dimnames被正确定义。
参数:annot
Matrix of annotations with at least one column named "EntrezGene.ID", dimnames being properly defined.
矩阵至少有一列名为“EntrezGene.ID”的注释,dimnames被正确定义。
参数:do.mapping
TRUE if the mapping through Entrez Gene ids must be performed (in case of ambiguities, the most variant probe is kept for each gene), FALSE otherwise.
TRUE如果通过Entrez基因ID的映射必须执行(含糊不清的情况下,每个基因保存最变种探针),FALSE否则。
参数:mapping
Matrix with columns "EntrezGene.ID" and "probe" used to force the mapping such that the probes are not selected based on their variance.
列“EntrezGene.ID”和“探针”使用强制映射探针没有被选中,根据其方差矩阵。
参数:do.prediction.strength
TRUE if the prediction strength must be computed (Tibshirani and Walther 2005), FALSE otherwise.
TRUE如果预测强度必须计算(Tibshirani和瓦尔特2005年),FALSE否则。
参数:do.BIC
TRUE if the Bayesian Information Criterion must be computed for number of clusters ranging from 1 to 10, FALSE otherwise.
TRUE如果必须为数字聚类从1到10不等,FALSE否则计算贝叶斯信息准则。
参数:plot
TRUE if the patients and their corresponding subtypes must be plotted, FALSE otherwise.
TRUE如果病人及其相应的亚型,必须绘制,FALSE否则。
参数:verbose
TRUE to print informative messages, FALSE otherwise.
TRUE打印翔实的消息,FALSE否则。
值----------Value----------
参数:subtype
Subtypes identified by the Subtype Clustering Model. Subtypes can be either "ER-/HER2-", "HER2+" or "ER+/HER2-".
亚型鉴定亚型聚类分析模型。亚型或者“ER-/HER2-”,“的HER2 +”或“ER阳性/ HER-2”。
参数:subtype.proba
Probabilities to belong to each subtype estimated by the Subtype Clustering Model.
概率属于由亚型聚类模型估计每个亚型。
参数:prediction.strength
Prediction strength for subtypes.
subtypes强度预测。
参数:BIC
Bayesian Information Criterion for the Subtype Clustering Model with number of clusters ranging from 1 to 10.
贝叶斯信息标准的数字聚类从1到10的亚型聚类分析模型。
参数:subtype2
Subtypes identified by the Subtype Clustering Model using AURKA to discriminate low and high proliferative tumors. Subtypes can be either "ER-/HER2-", "HER2+", "ER+/HER2- High Prolif" or "ER+/HER2- Low Prolif".
亚型鉴定亚型聚类模型使用AURKA区分高,低增生性肿瘤。亚型可无论是“ER-/HER2-”的HER2 +“,”ER阳性/ HER-2高增殖“或”ER / HER-2低增殖“。
参数:subtype.proba2
Probabilities to belong to each subtype (including discrimination between lowly and highly proliferative ER+/HER2- tumors, see subtype2) estimated by the Subtype Clustering Model.
概率属于每个亚型(包括卑微和高度增殖ER + / HER-2的肿瘤之间的歧视,看到subtype2)亚型聚类分析模型的估计。
参数:prediction.strength2
Prediction strength for subtypes2.
subtypes2强度预测。
参数:module.scores
Matrix containing ESR1, ERBB2 and AURKA module scores.
矩阵包含ESR1,ErbB2和AURKA模块分数。
参数:mapping
Mapping if necessary (list of matrices with 3 columns: probe, EntrezGene.ID and new.probe).
如果有必要的映射(3列的矩阵列表:探针,EntrezGene.ID和new.probe)。
作者(S)----------Author(s)----------
Benjamin Haibe-Kains
参考文献----------References----------
参见----------See Also----------
subtype.cluster, scmod1.robust, scmod2.robust
subtype.cluster,scmod1.robust,scmod2.robust
举例----------Examples----------
## load Subtype Clustering Model fitted on VDX[#负载亚型VDX的聚类分析模型上安装]
data(scmod1.robust)
## load NKI data[#负载NKI日经指数数据]
data(nkis)
## Subtype Clustering Model fitted on VDX and applied on NKI[#亚型VDX的研究和应用安装在NKI日经指数的聚类分析模型]
scmod1.nkis <- subtype.cluster.predict(sbt.model=scmod1.robust, data=data.nkis,
annot=annot.nkis, do.mapping=TRUE,
do.prediction.strength=FALSE, do.BIC=FALSE, plot=TRUE, verbose=TRUE)
table(scmod1.nkis$subtype)
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
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