findSynexprs(attract)
findSynexprs()所属R语言包:attract
This function finds the synexpression groups present within a core attractor pathway module.
此功能找到synexpression组内的核心吸引通路模块。
译者:生物统计家园网 机器人LoveR
描述----------Description----------
This function takes the modules that were inferred from the GSEA step using (findAttractors) and finds a set of transcriptionally coherent set of genes associated with a particular core attractor pathway, i.e. the synexpression groups.
此功能模块(findAttractors),并发现一套相干组与特定的核心吸引通路相关基因转录,即synexpression的群体,是从GSEA一步推断。
用法----------Usage----------
findSynexprs(pathwayIds, myAttractorModuleSet, removeGenes = NULL, min.clustersize = 5, ...)
参数----------Arguments----------
参数:pathwayIds
either a single character string or vector of character strings denoting the KEGG IDs of the pathway modules to be analyzed.
无论是单个字符的字符串或vector表示KEGG通路的标识字符字符串模块进行分析。
参数:myAttractorModuleSet
AttractorModuleSet object, output of the findAttractors step.
AttractorModuleSet对象,输出findAttractors一步。
参数:removeGenes
vector of gene names that specify those genes who demonstrate little variability across the different celltypes and thus should be removed from downstream analysis.
vector指定谁演示跨不同celltypes小的变异,因此应删除下游分析这些基因的基因名称。
参数:min.clustersize
integer specifying the minimum number of genes that must be present in clusters that are inferred.
integer指定最低的基因数量,必须在目前推断聚类。
参数:...
additional arguments.
额外的参数。
Details
详情----------Details----------
This function performs a hierarichical cluster analysis of the genes in a core attractor pathway module, and uses an informativeness metric to determine the number of optimal clusters (syenxpression groups) that describe the data.
执行此功能的核心吸引通路模块的基因hierarichical聚类分析,并使用信息量度量,以确定最佳聚类(syenxpression组),描述了数据的数量。
值----------Value----------
If a single KEGG ID is specified in pwayIds, then a SynExpressionSet object is returned. If a multiple KEGG IDs are specified, then an environment object is returned where the keys are labeled "pwayKEGGIDsynexprs" (e.g. for MAPK KEGGID = 04010, the key is pway04010synexprs). The value associated with each key is a SynExpressionSet object.
如果指定单一KEGG IDpwayIds,则SynExpressionSet对象返回。如果指定多个KEGG标识,然后返回键都标有“pwayKEGGIDsynexprs”(如MAPK的KEGGID = 04010,关键是pway04010synexprs)环境对象。与每个键关联的值是一个SynExpressionSet对象。
作者(S)----------Author(s)----------
Jessica Mar
参考文献----------References----------
举例----------Examples----------
data(subset.loring.eset)
attractor.states <- findAttractors(subset.loring.eset, "celltype", nperm=10, annotation="illuminaHumanv1.db")
remove.these.genes <- removeFlatGenes(subset.loring.eset, "celltype", contrasts=NULL, limma.cutoff=0.05)
mapk.syn <- findSynexprs("04010", attractor.states, remove.these.genes)
top5.syn <- findSynexprs(attractor.states@rankedPathways[1:5,1], attractor.states, removeGenes=remove.these.genes)
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
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