sigs(sigora)
sigs()所属R语言包:sigora
SIGORA's most important function
SIGORA最重要的功能
译者:生物统计家园网 机器人LoveR
描述----------Description----------
This function determines which Signatures (GPS) from SIGORA's collection of GPS data for the specified archive (pathway repository/database) are present in the specified list of genes of interest (samplename). It then uses the distribution function of hypergeometric probabilities to identify the pathways whose GPS are over-represented among the present GPS.
此功能确定指定列表中的基因的利益(samplename)签名(GPS)从SIGORA的GPS数据的采集指定的归档(通路库/数据库)。然后,它使用超几何概率分布函数,以确定代表在现时GPS的GPS的途径。
用法----------Usage----------
sigs(samplename, archive, markers, level = 1)
参数----------Arguments----------
参数:samplename
A user specified list of genes of interest ('query list'), as a vector of SIGORA IDs. To obtain such a vector, import the list of ENSEMBL/Entrez IDs using scan(..,what='character') and apply the appropriate mapping_function (entrez_converter or ens_converter) to it.
用户指定的感兴趣的基因列表(“查询列表”),作为向量的SIGORA标识。要获得这样的向量,导入列表的ENSEMBL / Entrez的ID,使用scan(..,what='character')和应用适当的mapping_function(entrez_converter或ens_converter)。
参数:archive
Repository name : e.g. keg(or 'k') for KEGG, 'R' for REACTOME. Possible values are 'K'(KEGG),'B'(PID_BIOCARTA),'N'(PID_NCI), 'I'(INOH),'R'(REACTOME).
库名称例如: KEGG,R为REACTOME桶(或“K”)。可能的值是“K”(KEGG),“B”(PID_BIOCARTA),N(PID_NCI),我(INOH),“R”(REACTOME)。
参数:markers
Whether to take single genes that are uniquely associated with only one pathway into account (i.e. should pathway unique genes/PUGs be considered GPS?). Choose from 0 (FALSE) and 1 (TRUE). Recommended value: 1.
无论是采取单一的唯一相关联的基因,只有一个途径考虑(即通路独特的基因/ PUGS的GPS?)。您可以选择从0(FALSE)1(TRUE)。推荐值:1。
参数:level
In hierarchical repositories (e.g. REACTOME) number of levels to consider. Recommended value for KEGG: 2, for REACTOME: 4.
在分层库(例如REACTOME)的水平考虑。推荐值KEGG:2,REACTOME:4。
值----------Value----------
Upon completion, the user is presented with the list of pathways that sigs deems to be statistically significant for this dataset. Additionally, sigs returns:
完成后,用户列表的途径,sigs认为该数据集有统计学意义。此外,sigs回报:
参数:detailed_results
The full list of present Signatures.
目前签名的完整列表。
参数:summary_results
The full list of pathways for which a present Signature was identified along with the associated values of the parameters of the hypergeometric function.
的签名被认定的途径以及相关的超几何函数的参数值的完整列表。
参见----------See Also----------
sigs_background, coexp_sigs
sigs_background,coexp_sigs
实例----------Examples----------
## Not run: [#不运行:]
sigs(dengue_hoang,'k',1,level=2)
## End(Not run)[#(不执行)]
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
注1:为了方便大家学习,本文档为生物统计家园网机器人LoveR翻译而成,仅供个人R语言学习参考使用,生物统计家园保留版权。
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