computeDatasetSignature(PREDA)
computeDatasetSignature()所属R语言包:PREDA
Function to compute dataset signature for recurrent significant genomic regions
函数来计算经常显着的基因组区域的数据集签名
译者:生物统计家园网 机器人LoveR
描述----------Description----------
Function to compute dataset signature for recurrent significant genomic regions
函数来计算经常显着的基因组区域的数据集签名
用法----------Usage----------
# computeDatasetSignature(.Object, genomicRegionsList=genomicRegionsList,
# multTestCorrection="fdr", signature_qval_threshold=0.05,
# returnRegions=TRUE, use.referencePositions=TRUE)
computeDatasetSignature(.Object, ...)
参数----------Arguments----------
参数:.Object
Object of class GenomicAnnotationsForPREDA
对象的类GenomicAnnotationsForPREDA
参数:...
See below
见下文
genomicRegionsList: List of genomicRegions objects for which the recurrent overlapping regions will be evaluated
genomicRegionsList:为genomicRegions经常重叠区域将被评估的对象名单
multTestCorrection: Multiple testing correction that will be adopted to correct the statistic p-values. Possible values are "fdr", for benjamini and Hochberg multiple testing correction and "qvalue" for p-values correction performed with qvalue package.
multTestCorrection:多个测试校正,将会采取什么措施来纠正统计p值。可能的值是“FDR”,为benjamini和Hochberg多个测试校正和与qvalue包执行的P-值校正的“qvalue”。
signature_qval_threshold: Threshold used to select significant regions resulting from the dataset signature statistic
signature_qval_threshold:阈值用来选择集签名统计的重要区域
returnRegions: Logical, if TRUE (default) the genomic regions constituting the daaset signature are returned, otherwise a PREDAresults object containing dataset signature statistics is returned.
returnRegions:逻辑,如果为TRUE(默认)的基因组区域构成daaset签名返回,否则PREDAresults集签名统计对象,其中包含返回。
use.referencePositions: Logical, if TRUE the input reference positions used for PREDA analysis wil be used to identify significant genomic regions boundaries as well.
use.referencePositions:逻辑,如果真正用于普雷达分析WIL输入参考位置被用来确定以及显著的基因组区域的边界。
Details
详情----------Details----------
The function adopts a binomial test to identify significant recurrence of genomic regions across multiple dataset sampels.
该功能采用了二项式测试,以确定多个集sampels的基因组区域的显着复发。
值----------Value----------
A GenomicRegions object (if returnRegions = TRUE) or a PREDAresults object containing dataset signature statistics (if returnRegions = FALSE)
一个GenomicRegions对象的(如果returnRegions = TRUE)或PREDAresults的对象,其中包含的数据集签名统计(如果returnRegions = FALSE时)
作者(S)----------Author(s)----------
Francesco Ferrari
参见----------See Also----------
GenomicRegions, PREDAResults
GenomicRegions,PREDAResults
举例----------Examples----------
## Not run: [#无法运行:]
require(PREDAsampledata)
data(SODEGIRCNanalysisResults)
data(GEDataForPREDA)
SODEGIR_CN_GAIN<-PREDAResults2GenomicRegions(
SODEGIRCNanalysisResults, qval.threshold=0.01,
smoothStatistic.tail="upper", smoothStatistic.threshold=0.1)
CNgain_signature<-computeDatasetSignature(GEDataForPREDA,
genomicRegionsList=SODEGIR_CN_GAIN)
## End(Not run)[#结束(不运行)]
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注:
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