ratiosummarization(isobar)
ratiosummarization()所属R语言包:isobar
protein and peptide ratios
蛋白质和多肽的比例
译者:生物统计家园网 机器人LoveR
描述----------Description----------
A set of functions to create ratios within groups and summarize them. proteinRatios serves as hub and calls combn.matrix, combn.protein.tbl and summarize.ratios successively. It can be used to calculate intra-class and inter-class ratios, to assess ratios and variability within and over cases.
一组函数来创建组内的比率,并总结他们。 proteinRatios作为枢纽和调用combn.matrix,combn.protein.tbl和summarize.ratios先后。它可以用来计算类内和类间的比率,评估及以上情况比率和变异。
用法----------Usage----------
proteinRatios(ibspectra, noise.model, reporterTagNames = NULL, proteins = reporterProteins(proteinGroup(ibspectra)), peptide = NULL, cl = classLabels(ibspectra), method = "global", symmetry = FALSE, summarize = FALSE, summarize.method = "mult.pval", min.detect = NULL, strict.sample.pval = TRUE, strict.ratio.pval = TRUE, orient.div = 0, sign.level = 0.05, sign.level.rat = sign.level, sign.level.sample = sign.level, ratiodistr = NULL, variance.function = "maxi", combine=FALSE,
p.adjust = NULL, reverse=FALSE, combn=NULL, ...)
combn.matrix(x, method = "global", cl = NULL)
combn.protein.tbl(ibspectra, noise.model, ratiodistr, proteins = NULL, cmbn, peptide = NULL, modif = NULL, symmetry = FALSE, reverse = FALSE, variance.function = "maxi", ...)
summarize.ratios(ratios, summarize.method, min.detect, n.combination, strict.sample.pval = TRUE, strict.ratio.pval = TRUE, orient.div = 0, sign.level = 0.05, sign.level.rat = sign.level, sign.level.sample = sign.level, variance.function = "maxi", ratiodistr, p.adjust = NULL)
参数----------Arguments----------
参数:ibspectra
IBSpectra object
IBSpectra对象
参数:x
for combn.matrix: reporter names. See reporterTagNames. argument of proteinRatios.
combn.matrix:记者名称。看到reporterTagNames。参数proteinRatios。
参数:ratios
result of combn.protein.tbl
导致的combn.protein.tbl
参数:cmbn
result of combn.matrix
导致的combn.matrix
参数:combn
result of combn.matrix
导致的combn.matrix
参数:noise.model
NoiseModel for spectra variances
NoiseModel的光谱差异
参数:reporterTagNames
Reporter tags to use. By default all reporterTagNames of ibspectra object.
记者标签使用。默认情况下,所有reporterTagNames ibspectra对象。
参数:proteins
proteins for which ratios are calculated - defaults to all proteins with peptides specific to them.
比率计算的蛋白质 - 默认为所有的蛋白质与他们特定的肽。
参数:peptide
peptides for which ratios are calculated.
肽比率计算。
参数:modif
Modification.
修改。
参数:cl
Class labels. See also ?classLabels.
类的标签。还可以看吗?classLabels。
参数:method
"global", "interclass", or "intra-class". Defines which ratios are computed, based on class labels cl
“全球”,“组间”,或“内部类”。定义比率计算,基于类的标签CL
参数:symmetry
If true, reports also the inverse ratio
如果情况属实,报告还反比
参数:summarize
If true, ratios for each protein are summarized.
如果情况属实,每个蛋白的比率进行了总结。
参数:summarize.method
"isobar", for now.
“压线”,现在。
参数:min.detect
How many times must a ratio for a protein be present when summarizing? When NULL, defaults to the maximum number of combinations.
必须的一种蛋白质的比例是多少次时总结?当空,默认的最大数量的组合。
参数:strict.sample.pval
If true, missing ratios are penalized by giving them a sample.pval of 0.5.
如果为true,丢失率,给他们一个0.5 sample.pval处罚。
参数:strict.ratio.pval
If true, take all ratios into account. If false, only take ratios into account which are in the same direction as the majority of ratios
如果情况属实,考虑到所有的比率。如果为false,只考虑在同一方向,为广大的比率的比率
参数:orient.div
Number of ratios which might go in the wrong direction.
数比率可能在错误的方向去。
参数:sign.level
Significance level
显着性水平
参数:sign.level.rat
Significance level on ratio p-value
比p值显着性水平
参数:sign.level.sample
Significance level on sample p-value
对样品的p值的显着性水平
参数:ratiodistr
Protein ratio distribution
蛋白质比例分布
参数:variance.function
Variance function
方差函数
参数:...
Passed to estimateRatio()
传递到estimateRatio的()
参数:combine
If true, a single ratio for all proteins and peptides, resp., is calculated. See estimateRatio.
如果情况属实,所有的蛋白质和多肽,分别为单比率,计算。看到estimateRatio。
参数:p.adjust
Set to one of p.adjust.methods to adjust ratio p-values for multiple comparisions. See p.adjust.
设置p.adjust.methods比p-值调整为多重比较。看到p.adjust。
参数:reverse
reverse
逆转
参数:n.combination
numbero fo combinations possible
numbero FO组合可能
值----------Value----------
'data.frame': 11 variables:
“数据框”:11个变量:
参数:lratio
log ratio
登录率
参数:variance
variance
方差
参数:n.spectra
Number of spectra used for quantification
光谱定量号码
参数:p.value.rat
Signal p-value (NA if ratiodistr is missing)
信号p值(不适用,如果ratiodistr缺少)
参数:p.value.sample
Sample p-value (NA if ratiodistr is missing)
样品的p值(不适用,如果ratiodistr丢失)
参数:is.significant
Is the ratio significant? (NA if ratiodistr is missing)
是显著的比例? (不适用,如果ratiodistr丢失)
参数:protein
Protein quantified
蛋白质定量
参数:r1
r1
R1
参数:r2
r2
R2
作者(S)----------Author(s)----------
Florian P Breitwieser, Jacques Colinge
参见----------See Also----------
IBSpectra, isobar-preprocessing isobar-analysis
IBSpectra,压线,预处理等压线分析
举例----------Examples----------
combn.matrix(114:117,method="interclass",cl=as.character(c(1,1,2,2)))
combn.matrix(114:117,method="interclass",cl=as.character(c(1,1,2,2)))
combn.matrix(114:117,method="global")
data(ibspiked_set1)
data(noise.model.hcd)
ceru.proteins <- c("P13635","Q61147")
proteinRatios(ibspiked_set1,noise.model=noise.model.hcd,proteins=ceru.proteins,cl=c("T","T","C","C"),method="interclass",summarize=TRUE)
转载请注明:出自 生物统计家园网(http://www.biostatistic.net)。
注:
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